KMID : 0644120120250020023
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Journal of Oriental Gynecology 2012 Volume.25 No. 2 p.23 ~ p.42
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Effects of Samkieumgamibang Extract on Osteoclast Differentiation and Osteoblast Function
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Park Sun-Min
Yoo Dong-Youl
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Abstract
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Objectives: This study was performed to evaluate the effect of Samkieumgamibang (SKG) on osteoporosis.
Methods: The osteoclastogenesis and gene expression were determined in RANKL-stimulated RAW 264.7 cell. And, osteoblastogenesis was also determined in rat calvarial cell.
Results: SKG decreased the number of TRAP positive cell in osteoclast. It also decreased the expression of Cathepsin K, MMP-9, TRAP, c-fos, NAFTc1 and JNK1 in osteoclast. SKG increased the expression of iNOS in RANKL-stimulated in osteoclast. Otherwise, SKG inhibited TRAP activity in osteoclast. SKG increased cell proliferation, ALP activity, bone martix protein, collagen and nodule in osteoblast.
Conclusions: It is concluded that SKG might decrease the bone resorption resulted from decrease of osteoclast differentiation and it¡¯s related gene expression. And, SKG might increase the bone formation resulted from increase of osteoblast function.
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KEYWORD
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Samkieumgamibang(SKG), Osteoclast, Osteoblast, Osteoporosis, Bone resorption
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